Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake.

@article{Mulari2003OsteoclastRB,
  title={Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake.},
  author={Mika T.K. Mulari and Haibo Zhao and P{\"a}ivi T. Lakkakorpi and H. Kalervo V{\"a}{\"a}n{\"a}nen},
  journal={Traffic},
  year={2003},
  volume={4 2},
  pages={113-25}
}
Subosteoclastic bone resorption is a result of HCl and proteinase secretion through a late endosome-like bone facing membrane domain called ruffled border. As bone matrix is degraded, it enters osteoclasts' transcytotic vesicles for further processing and is then finally exocytosed to the intercellular space. The present study clarifies the spatial relationship between these vesicle fusion and matrix uptake processes at the ruffled border. Our results show the presence of vacuolar H+-ATPase… CONTINUE READING