Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss.

@article{Barsony2011OsteoclastRT,
  title={Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss.},
  author={Julia Barsony and Yoshihisa Sugimura and Joseph G. Verbalis},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 12},
  pages={10864-75}
}
Our recent animal and human studies revealed that chronic hyponatremia is a previously unrecognized cause of osteoporosis that is associated with increased osteoclast numbers in a rat model of the human disease of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). We used cellular and molecular approaches to demonstrate that sustained low extracellular sodium ion concentrations ([Na(+)]) directly stimulate osteoclastogenesis and resorptive activity and to explore the… CONTINUE READING