Osteoclast motility: putting the brakes on bone resorption.


As the skeleton ages, the balanced formation and resorption of normal bone remodeling is lost, and bone loss predominates. The osteoclast is the specialized cell that is responsible for bone resorption. It is a highly polarized cell that must adhere to the bone surface and migrate along it while resorbing, and cytoskeletal reorganization is critical… (More)
DOI: 10.1016/j.arr.2009.09.005