Osteoclast formation and bone resorption are inhibited by megakaryocytes.

Abstract

It has been previously reported that addition of megakaryocytes (MKs) to osteoblasts in vitro results in increased osteoblastic collagen and osteoprotegerin (OPG) production, suggesting a role for MKs in bone formation. To further investigate this role, we have studied the effects of MKs on osteoclast formation and activity. Human osteoclasts were generated… (More)
DOI: 10.1016/j.bone.2006.06.004

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