Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL

@article{Huang2006OsteoclastDR,
  title={Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL},
  author={H Huang and J Ryu and Joohun Ha and E-J Chang and Hyun-Man Kim and Tetsuya Kitamura and Zang Hee Lee and H J Kim},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={1879-1891}
}
Osteoclast (Oc) differentiation is fundamentally controlled by receptor activator of nuclear factor kappaB ligand (RANKL). RANKL signalling targets include mitogen-activated protein kinases (MAPKs), nuclear factor kappaB (NF-κB), and nuclear factor of activated T cells (NFAT)c1. In this study, we found that p38 MAPK upstream components transforming growth factor-beta-activated kinase 1 (TAK1), MKK3, and MKK6 increased by RANKL in an early stage of osteoclastogenesis from primary bone marrow… CONTINUE READING

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Signal TransductionProcess involves geneMAP2K6 gene
These results indicate that TAK1 and MKK6 constitute the p38 signalling pathway to participate to Oc differentiation by RANKL through p65 phosphorylation and NFATc1 induction , and that MKK6 and MKK3 have differential roles in osteoclastogenesis from bone marrow precursors .
Signal TransductionProcess involves geneNFATC1 gene
These results indicate that TAK1 and MKK6 constitute the p38 signalling pathway to participate to Oc differentiation by RANKL through p65 phosphorylation and NFATc1 induction , and that MKK6 and MKK3 have differential roles in osteoclastogenesis from bone marrow precursors .
These results indicate that TAK1 and MKK6 constitute the p38 signalling pathway to participate to Oc differentiation by RANKL through p65 phosphorylation and NFATc1 induction , and that MKK6 and MKK3 have differential roles in osteoclastogenesis from bone marrow precursors .
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