Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.

@article{Matsuzaki1998OsteoclastDF,
  title={Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.},
  author={Kenichiro Matsuzaki and Nobuyuki Udagawa and Naoyuki Takahashi and Kiyoshi Yamaguchi and Hiroshi Yasuda and Nobuyuki Shima and Takatoshi Morinaga and Yoshiaki Toyama and Yuki Yabe and Kanji Higashio and Tatsuo Suda},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={246 1},
  pages={199-204}
}
We have reported that osteoclast differentiation factor (ODF) expressed on the plasma membrane of osteoblasts/ stromal cells is a ligand for osteoclastogenesis inhibitory factor (OCIF). A genetically engineered soluble form of ODF (sODF) induced osteoclast-like multinucleated cells (OCLs) in the presence of M-CSF in mouse spleen cell cultures. Osteoblasts/stromal cells were not required in this process. To elucidate the mechanism of human osteoclastogenesis, human peripheral blood mononuclear… CONTINUE READING

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