Osteoclast activating factor is now interleukin-1 beta: historical perspective and biological implications.

@article{Jandinski1988OsteoclastAF,
  title={Osteoclast activating factor is now interleukin-1 beta: historical perspective and biological implications.},
  author={John J Jandinski},
  journal={Journal of oral pathology},
  year={1988},
  volume={17 4},
  pages={145-52}
}
Interleukin-1 (IL-1) represents a family of polypeptides with widespread immunological and non-immunological activity. Recent studies show that osteoclast activating factor (OAF) is homologous to IL-1B. In this review, the biological properties, cell sources and actions of IL-1 are discussed. The numerous biological effects of IL-1 on various host systems suggest that elevated levels of the mediator may be an indicator of a pathological process. Since the IL-1 family plays an important role as… CONTINUE READING

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