Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation.

@article{Weivoda2016OsteoclastTR,
  title={Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation.},
  author={Megan Moore Weivoda and Ming M Ruan and Larry R Pederson and Christine M Hachfeld and Rachel A. Davey and Jeffrey D. Zajac and Jennifer J Westendorf and Sundeep Khosla and Merry Jo Oursler},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2016},
  volume={31 1},
  pages={76-85}
}
Osteoblast-mediated bone formation is coupled to osteoclast-mediated bone resorption. These processes become uncoupled with age, leading to increased risk for debilitating fractures. Therefore, understanding how osteoblasts are recruited to sites of resorption is vital to treating age-related bone loss. Osteoclasts release and activate TGF-β from the bone matrix. Here we show that osteoclast-specific inhibition of TGF-β receptor signaling in mice results in osteopenia due to reduced osteoblast… CONTINUE READING
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