Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption.

@article{Shashkova2016OsteoclastPrimedFC,
  title={Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption.},
  author={Elena V. Shashkova and Jahnavi Trivedi and Anna B Cline-Smith and Chloe Ferris and Zachary S. Buchwald and Jesse Gibbs and Deborah V Novack and Rajeev Aurora},
  journal={Journal of immunology},
  year={2016},
  volume={197 3},
  pages={726-35}
}
Osteoimmunology arose from the recognition that cytokines produced by lymphocytes can affect bone homeostasis. We have previously shown that osteoclasts, cells that resorb bone, act as APCs. Cross-presentation of Ags by osteoclasts leads to expression of CD25 and Foxp3, markers of regulatory T cells in the CD8 T cells. Octeoclast-induced Foxp3(+) CD25(+) regulatory CD8 T cells (OC-iTcREG) suppress priming of CD4 and CD8 T cells by dendritic cells. OC-iTcREG also limit bone resorption by… CONTINUE READING