Osteochondral tissue engineering using a biphasic collagen/GAG scaffold containing rhFGF18 or BMP-7 in an ovine model

@inproceedings{Getgood2014OsteochondralTE,
  title={Osteochondral tissue engineering using a biphasic collagen/GAG scaffold containing rhFGF18 or BMP-7 in an ovine model},
  author={Alan Getgood and Frances Henson and Carrie Skelton and Roger A. Brooks and Hans Guehring and Lisa A Fortier and Neil Rushton},
  booktitle={Journal of experimental orthopaedics},
  year={2014}
}
BACKGROUND The aim of this study was to investigate the effect of combining rhFGF18 or BMP-7 with a biphasic collagen/GAG osteochondral scaffold (Chondromimetic) on the repair of osteochondral defects in sheep. METHODS Osteochondral defects (5.8x6mm) were created in the medial femoral condyle (MFC) and the lateral trochlea sulcus (LTS) of the stifle joint of 24 female sheep. Sheep were randomly assigned to four groups (n = 6); 1) empty defect, 2) scaffold only, 3) scaffold + rhFGF-18 (30 μg… CONTINUE READING
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