Osteochondral regeneration by a bilayered construct in a cell-free or cell-based approach

@article{Cao2012OsteochondralRB,
  title={Osteochondral regeneration by a bilayered construct in a cell-free or cell-based approach},
  author={Zheng Cao and Shuxun Hou and Daming Sun and Xiaoning Wang and Junjun Tang},
  journal={Biotechnology Letters},
  year={2012},
  volume={34},
  pages={1151-1157}
}
A bilayered construct with or without adipose-derived stem cells (ASCs) was applied to repair full-thickness defects in the patellar groove of 18 rabbits. Non-treated and treated defects were divided into three groups: a control group (n = 12), a cell-free group (n = 12) and a cell-based group (n = 12). Histological appearance and grading were evaluated at 8 and 12 weeks. At 12 weeks, osteochondral-like tissues completely filled in the defects and integrated with host tissues in the cell-based… CONTINUE READING