Osteocalcin is angiogenic in vivo.

Abstract

The exact function of osteocalcin (OC), a protein synthesized by osteoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti-angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF-2, a well-known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation.

Statistics

020040020102011201220132014201520162017
Citations per Year

171 Citations

Semantic Scholar estimates that this publication has 171 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Cantatore2005OsteocalcinIA, title={Osteocalcin is angiogenic in vivo.}, author={Francesco Paolo Cantatore and Enrico Crivellato and Domenico Ribatti}, journal={Cell biology international}, year={2005}, volume={29 7}, pages={583-5} }