Osteoblastic insufficiency is responsible for maintenance of osteopenia after loss of ovarian function in experimental beagle dogs.

@article{Malluche1986OsteoblasticII,
  title={Osteoblastic insufficiency is responsible for maintenance of osteopenia after loss of ovarian function in experimental beagle dogs.},
  author={Hartmut H. Malluche and Marie Claude Faugere and Margaret L Rush and Robert Friedler},
  journal={Endocrinology},
  year={1986},
  volume={119 6},
  pages={
          2649-54
        }
}
Bone loss developing after cessation of ovarian function in humans represents a major health problem. To establish the value of ovariohysterectomy in female beagle dogs as a model for bone loss and to study static and dynamic parameters of bone associated with the negative bone balance occurring after cessation of ovarian function, we performed iliac crest bone biopsies before and 4 months after ovariohysterectomy in eight beagle dogs and in five sham-operated controls. Cessation of ovarian… CONTINUE READING
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