Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone.

@article{Carpenter2010OsteoblasticDO,
  title={Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone.},
  author={Ryan Carpenter and Laurie R. Goodrich and David D. Frisbie and John David Kisiday and Beth Duda Carbone and C W Mcilwraith and Christopher J. Centeno and Chisa Hidaka},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2010},
  volume={28 10},
  pages={1330-7}
}
Bone marrow-derived mesenchymal stem cells (BMDMSCs) have been targeted for use in enhancement of bone healing; and their osteogenic potential may be further augmented by genes encoding bone morphogenetic proteins (BMP's). The purpose of this study was to compare the effect of genetic modification of human and equine BMDMSCs with BMP-2 or -7 or BMP-2 and -7 on their osteoblastogenic differentiation in the presence or absence of dexamethasone. The BMDMSCs were harvested from the iliac crest of… CONTINUE READING
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