Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs.

@article{Cordonnier2014OsteoblasticDA,
  title={Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs.},
  author={Thomas Cordonnier and Alain Langonn{\'e} and Pierre Corre and Audrey Renaud and Luc Sens{\'e}b{\'e} and Philippe Rosset and Pierre Layrolle and Jerome Sohier},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2014},
  volume={8 5},
  pages={364-76}
}
Bone tissue engineering usually consists of associating osteoprogenitor cells and macroporous scaffolds. This study investigated the in vitro osteoblastic differentiation and resulting in vivo bone formation induced by a different approach that uses particles as substrate for human bone marrow stromal cells (hBMSCs), in order to provide cells with a higher degree of freedom and allow them to synthesize a three-dimensional (3D) environment. Biphasic calcium phosphate (BCP) particles (35 mg, ~175… CONTINUE READING
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