Osteoblast responses to nucleotides increase during differentiation.

  title={Osteoblast responses to nucleotides increase during differentiation.},
  author={Isabel R Orriss and Gillian E. Knight and Sam Ranasinghe and Geoffrey Burnstock and Timothy Arnett},
  volume={39 2},
Accumulating evidence suggests that extracellular nucleotides, signaling through P2 receptors, play a role in modulating bone cell function. ATP and ADP stimulate osteoclastic resorption, while ATP and UTP are powerful inhibitors of bone formation by osteoblasts. We investigated changes in the expression of P2 receptors with cell differentiation in primary osteoblast cultures. Rat calvarial osteoblasts, cultured for up to 10 days, were loaded with the intracellular Ca(2+)-sensing fluorophore… CONTINUE READING
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Expression of P 2 receptors in

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P2X2 but not P2X3 receptor knockout mice demonstrate increased bone mass and weight

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