Osteoblast-derived lipocalin-2 regulated by miRNA-96-5p/Foxo1 advances the progression of Alzheimer's disease.

@article{Wu2020OsteoblastderivedLR,
  title={Osteoblast-derived lipocalin-2 regulated by miRNA-96-5p/Foxo1 advances the progression of Alzheimer's disease.},
  author={Bowen Wu and Jin-Dong Guo and Mi-Shan Wu and Yu Liu and Meng Lu and Yuhui Zhou and Hong Han},
  journal={Epigenomics},
  year={2020}
}
Aim: Alzheimer's disease (AD) is the most frequent cause of dementia and characterized by the accumulation of β-amyloid peptides in plaques and vessel walls. This study proposed a hypothesis of an inhibitory role of miR-96-5p in AD via regulating Foxo1. Methods & methods: AD mouse models were established by injecting with 1% pentobarbital. Results: Knockdown of miR-96-5p in the presence of naringin was shown to reduce the expression of Foxo1 and contents of superoxide dismutase, catalase and… 
4 Citations
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Investigation of the differential expression of ATP-binding cassette A1 (ABCA1) and its upstream microRNA (miRNA) in AD models found that miR-96-5p is the upstream miRNA for ABCA1 and plays an important role in regulating the content of Aβ.
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