Osteoblast-derived lipocalin-2 regulated by miRNA-96-5p/Foxo1 advances the progression of Alzheimer's disease.

  title={Osteoblast-derived lipocalin-2 regulated by miRNA-96-5p/Foxo1 advances the progression of Alzheimer's disease.},
  author={Bowen Wu and Jin-Dong Guo and Mi-Shan Wu and Yu Liu and Meng Lu and Yuhui Zhou and Hong Han},
Aim: Alzheimer's disease (AD) is the most frequent cause of dementia and characterized by the accumulation of β-amyloid peptides in plaques and vessel walls. This study proposed a hypothesis of an inhibitory role of miR-96-5p in AD via regulating Foxo1. Methods & methods: AD mouse models were established by injecting with 1% pentobarbital. Results: Knockdown of miR-96-5p in the presence of naringin was shown to reduce the expression of Foxo1 and contents of superoxide dismutase, catalase and… 
4 Citations
Inhibition of miR-96-5p May Reduce Aβ 42/Aβ40 Ratio via Regulating ATP-Binding Cassette A1.
Investigation of the differential expression of ATP-binding cassette A1 (ABCA1) and its upstream microRNA (miRNA) in AD models found that miR-96-5p is the upstream miRNA for ABCA1 and plays an important role in regulating the content of Aβ.
Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca2+ Homeostasis in Hippocampus; Relevance to Neurodegenerative Disorders
A significant increase in expression of Lcn2, S 100a8, S100a9 and also Saa3 and Ch25h, was found in AD brains suggesting that early changes of immune-response genes evoked by mild SIR could be crucial in AD pathogenesis.
Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy
This review examines natural products that have the potential to effectively treat MS and elucidate the regulated mechanisms acting upon EAE by the flavonoids, glycosides, and triterpenoids derived from natural products.


Perspectives in Lipocalin-2: Emerging Biomarker for Medical Diagnosis and Prognosis for Alzheimer's Disease
It may suggest that the manipulation of LCN2 in the CNS would be a crucial target for regulation of the pathogenesis and risk of AD.
MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification
MiR-32 was identified as a critical modulator and potential diagnostic marker for CAC and promoted promotion of VSMC calcification in mice through the enhanced expression of bonemorphogenetic protein-2, runt-related transcription factor-2(RUNX2), osteopontin, and the bone-specific phosphoprotein matrix GLA protein in vitro.
miR-96 regulates FOXO1-mediated cell apoptosis in bladder cancer.
This study demonstrates that the miR-96 targeting of FOXO1 is upregulated in TCC; in addition, TCC tumorigenesis may be partly due to the ability of miR -96 to promote FoxO1 repression, thereby bypassing cell apoptosis controls.
Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications
Mechanisms and genes linking autophagy and AD, i.e., the mTOR pathway, neuroinflammation, endocannabinoid system, ATG7, BCL2, BECN1, CDK5, CLU, CTSD, FOXO1, GFAP, ITPR1, MAPT, PSEN1, SNCA, UBQLN 1, and UCHL1 are discussed.
Lipocalin 2: Novel component of proinflammatory signaling in Alzheimer's disease
  • P. Naudé, C. Nyakas, U. Eisel
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2012
Lcn2 silences a TNFR2‐mediated protective neuronal signaling cascade in neurons, pivotal for TNF‐a‐mediated neuroprotection, and is introduced as a molecular actor in neuroinflammation in early clinical stages of AD.
Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels
A diurnal fluctuation of GSH levels is correlated with neuroprotective activity against oxidative stress in dopaminergic cells and it is found that the cysteine transporter excitatory amino acid carrier 1 (EAAC1), which is involved in neuronal GSH synthesis, is negatively regulated by the microRNA miR-96-5p, which exhibits a diurnal rhythm.
MicroRNA-96 plays an oncogenic role by targeting FOXO1 and regulating AKT/FOXO1/Bim pathway in papillary thyroid carcinoma cells.
MicroRNAs (miRNAs) are kind of small non-coding RNAs that negatively regulate gene expression at post-transcription level, and those non-coding RNAs appear to play a key role in tumorigenesis. The
microRNAs: Emerging Targets Regulating Oxidative Stress in the Models of Parkinson's Disease
Relevant miRNAs involved in oxidative stress can prevent ROS-mediated damage to DA neurons, suggesting that specific miRNas may be putative targets for novel therapeutic targets in PD.