Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor β (TGFβ) signaling.

@article{Karlsson2018OsteoblastderivedFP,
  title={Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor β (TGFβ) signaling.},
  author={Terese Karlsson and Reshma Sundar and Anders Widmark and Mar{\'e}ne Landstr{\"o}m and Emma Persson},
  journal={The Prostate},
  year={2018},
  volume={78 6},
  pages={446-456}
}
BACKGROUND Transforming growth factor β (TGFβ) functions as a double-edged sword in prostate cancer tumorigenesis. In initial stages of the disease, TGFβ acts as a growth inhibitor upon tumor cells, whereas it in later stages of disease rather promotes invasion and metastatic potential. One well-known cellular source of TGFβ in the bone metastatic site is the bone-forming osteoblasts. Here we have studied the effects by osteoblast-derived factors on metastatic potential in several human… CONTINUE READING