Osteoblast-derived FGF9 regulates skeletal homeostasis.

@article{Wang2017OsteoblastderivedFR,
  title={Osteoblast-derived FGF9 regulates skeletal homeostasis.},
  author={Liping Wang and Theresa Roth and Marcia J Abbott and Linh Thuy Ho and Lalita Wattanachanya and Robert A. Nissenson},
  journal={Bone},
  year={2017},
  volume={98},
  pages={
          18-25
        }
}
FGF9 has complex and important roles in skeletal development and repair. We have previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein signaling and therefore the present study was done to determine whether OB-derived FGF9 was important in skeletal homeostasis. To directly test this idea, we deleted functional expression of Fgf9 gene in OBs using a 2.3kb collagen type I promoter-driven Cre transgenic mouse line (Fgf9OB-/-). Both Fgf9 knockout (Fgf9OB-/-) and… CONTINUE READING
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