Osteoblast-conditioned media influence the expression of E-selectin on bone-derived vascular endothelial cells.

@article{Makuch2006OsteoblastconditionedMI,
  title={Osteoblast-conditioned media influence the expression of E-selectin on bone-derived vascular endothelial cells.},
  author={Lauren A Makuch and Donna M. Sosnoski and Carol V. Gay},
  journal={Journal of cellular biochemistry},
  year={2006},
  volume={98 5},
  pages={1221-9}
}
Breast cancer cells frequently metastasize to the ends of long bones, ribs and vertebrae, structures which contain a rich microvasculature that is closely juxtaposed to metabolically active trabecular bone surfaces. This study focuses on the effects of osteoblast secretions on the surface presentation of adhesive proteins on skeletal vascular endothelial cells. Vascular endothelial cells were isolated from trabecular bone regions of the long bones of 7-week-old Swiss Webster mice and also from… CONTINUE READING