Osteoblast and osteoclast differentiation in modeled microgravity.

  title={Osteoblast and osteoclast differentiation in modeled microgravity.},
  author={Ritu Saxena and George Pan and J. M. Mcdonald},
  journal={Annals of the New York Academy of Sciences},
Prolonged microgravity experienced by astronauts is associated with a decrease in bone mineral density. To investigate the effect of microgravity on differentiation of osteoclasts and osteoblasts, we used a NASA-recommended, ground-based, microgravity-simulating system, the Rotary Cell Culture System (RCCS). Using the RCCS, we demonstrated that modeled microgravity (MMG) inhibited osteoblastogenesis and increased adipocyte differentiation in human mesenchymal stem cells incubated under… CONTINUE READING