Osteoarthritis year 2010 in review: pathomechanisms.

  title={Osteoarthritis year 2010 in review: pathomechanisms.},
  author={Wim B. van den Berg},
  journal={Osteoarthritis and cartilage},
  volume={19 4},
Osteoarthritis is characterized by progressive breakdown of articular cartilage. This review summarizes findings of the last year, which shed new light on mechanisms and factors involved in cartilage loss. Evidence is accumulating that the transcription factor hypoxia-inducible factor-2α (HIF-2α) is highly enhanced in OA cartilage and drives catabolic… CONTINUE READING