Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing.

@article{Kraan2008OsteoarthritisIT,
  title={Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing.},
  author={Peter M van der Kraan and Wim B. van den Berg},
  journal={Ageing research reviews},
  year={2008},
  volume={7 2},
  pages={106-13}
}
Ageing is the main risk factor of primary osteoarthritis (OA) and OA is the disease most strongly correlated with ageing. Both in humans and other animals OA development appears to be not strictly time-dependent but to hold pace with ageing processes. A characteristic of OA is deviant behaviour of chondrocytes in articular cartilage. These chondrocytes resemble terminal differentiated chondrocytes in growth plates and actively produce matrix degrading enzymes. The latter results in cartilage… CONTINUE READING

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