Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology.

@article{Blanco1998OsteoarthritisCD,
  title={Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology.},
  author={Francisco J Blanco and Ram{\'o}n Guiti{\'a}n and Eduardo V{\'a}zquez-Martul and Francisco Javier de Toro and Fausto Galdo},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 2},
  pages={284-9}
}
OBJECTIVE To determine which kind of cell death occurs in cartilage from patients with osteoarthritis (OA). METHODS Seven normal and 16 OA cartilage samples were collected at autopsy or during joint replacement surgery, respectively. A piece of cartilage was cryopreserved until histologic studies were done. The rest of the cartilage was used to isolate chondrocytes. Apoptotic chondrocytes were analyzed by light and fluorescence microscopy using nuclear 4',6-diamidino-2-phenylindole… CONTINUE READING

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