Osteoarthritis: pathobiology-targets and ways for therapeutic intervention.

  title={Osteoarthritis: pathobiology-targets and ways for therapeutic intervention.},
  author={Thomas Aigner and Anja Sachse and Pia Margarethe Gebhard and Helmtrud I. Roach},
  journal={Advanced drug delivery reviews},
  volume={58 2},
Osteoarthritis is first and foremost the ongoing destruction of the articular cartilages of joints. Therefore, the extracellular matrix and the cells of the articular cartilages are the primary targets of osteoarthritis therapy. This tries to inhibit enzymatic destruction of the extracellular cartilage matrix as well as the modification of the cellular phenotype of the chondrocytes: cell degeneration and cell death are alongside anabolic activation and stabilization of the cellular phenotype of… CONTINUE READING

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