Osteoarthritis, genetic and molecular mechanisms

@article{Ghosh2004OsteoarthritisGA,
  title={Osteoarthritis, genetic and molecular mechanisms},
  author={Peter Ghosh and Margaret M. Smith},
  journal={Biogerontology},
  year={2004},
  volume={3},
  pages={85-88}
}
Osteoarthritis (OA) is the most common musculoskeletal disorder world-wide and has enormous social and economic consequences. OA is a multifactorial disorder in which ageing, genetic, hormonal and mechanical factors are all major contributors to its onset and progression. The primary lesion in OA would appear to occur in the articular cartilage (AC) which covers the weight-bearing surfaces of diarthrodial joints. Studies on AC have shown a decline in the chondrocyte numbers and their viability… 
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