Osteoarthritis, genetic and molecular mechanisms
@article{Ghosh2004OsteoarthritisGA, title={Osteoarthritis, genetic and molecular mechanisms}, author={Peter Ghosh and Margaret M. Smith}, journal={Biogerontology}, year={2004}, volume={3}, pages={85-88} }
Osteoarthritis (OA) is the most common musculoskeletal disorder world-wide and has enormous social and economic consequences. OA is a multifactorial disorder in which ageing, genetic, hormonal and mechanical factors are all major contributors to its onset and progression. The primary lesion in OA would appear to occur in the articular cartilage (AC) which covers the weight-bearing surfaces of diarthrodial joints. Studies on AC have shown a decline in the chondrocyte numbers and their viability…
71 Citations
Mechanobiology of articular cartilage : Consequences of physical activity and advanced glycation
- Biology, Engineering
- 2017
The observations proved the dynamic nature of bone turnover which continuously reacts to forces as well as cartilage/chondrocyte mechano-sensitive responses to mechanical stimuli and found that the cartilage stiffness as determined from indentation tests is highly dependent on indentation and indenter characteristics has a very high spatial variability.
Hoffa's Fat Pad Abnormality in the Development of Knee Osteoarthritis.
- Medicine, BiologyAdvances in experimental medicine and biology
- 2018
The importance of Hoffa's fat pad in the development and progression of osteoarthritis is overviewed, which shows its role in the activation and release of pro-inflammatory mediators in the degenerative joint disease.
The Role of Inflammatory Cytokine and Inflammatory Regulator Protein Related to Severity of Joint Effusion in Osteoarthritis
- Medicine
- 2020
Pro-inflammatory cytokines of TNF-alpha and IL-1B, and the transcription factors of pro- inflammatory cytokines gene expression, NFATC1, and C1orf38, did not correlate with the severity of joint effusion in OA.
Ultrastructural changes of the articular cartilage in some arthropathies with special reference to chondrocyte cell death.
- MedicineThe Malaysian journal of pathology
- 2003
Evidence is provided that apoptosis may contribute to the cartilage breakdown not only in RA and OA but also in the seronegative spondyloarthritides, which had a significantly higher apoptotic rate than the normal cartilage.
Osteoarthritis: current treatment and future prospects for surgical, medical, and biologic intervention.
- MedicineClinical orthopaedics and related research
- 2004
Current practices in medical, pharmaceutical and surgical treatment are reviewed with a perspective toward the immediate, distant and far distant future of osteoarthritis.
Nitric oxide production in association with osteoarthritis
- Medicine
- 2007
It is concluded that modulation of NO synthesis and action could represent a new approach to the treatment of osteoarthritis.
Effects of interleukin-1beta on chondroblast viability and extracellular matrix changes in bovine articular cartilage explants.
- BiologyBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2003
Growth and development: hereditary and mechanical modulations.
- BiologyAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
- 2004
The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review.
- Biology, MedicineOsteoarthritis and cartilage
- 2010
Association of metalloproteinases, tissue inhibitors of matrix metalloproteinases, and proteoglycans with development, aging, and osteoarthritis processes in mouse temporomandibular joint
- BiologyHistochemistry and Cell Biology
- 2003
Temporal codistribution of PGs, MMPs, and TIMPs during skeletal maturation reflected an active growth phase, whereas their reduction coincided with the more quiescent articulating and maintenance phase in the joint cartilage.
References
SHOWING 1-10 OF 23 REFERENCES
Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
- Medicine, BiologyArthritis and rheumatism
- 2000
The finding that increasing OA score was associated with a reduced response to intact IGF-1 but not des(1-3) IGF- 1 suggests a role of increased production of inhibitory IGFBP in OA.
The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment.
- Medicine, BiologySeminars in arthritis and rheumatism
- 1999
Synovial membrane inflammation and cytokine production in patients with early osteoarthritis.
- Medicine, BiologyThe Journal of rheumatology
- 1997
Chronic inflammatory changes with production of proinflammatory cytokines are a feature of synovial membranes from patients with early OA, with the most severe changes seen in patients at the time of joint replacement surgery resembling those seen in rheumatoid arthritis.
Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures.
- BiologyBiomaterials
- 1992
Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 1996
The observation that IGFBP-3 and -5 expression and production are elevated in osteoarthritic cartilage suggests that they may be acting as a competitor for IGF-I in arthritis, thus reducing the anabolic stimulation of this tissue and contributing to the net loss of cartilage in this disease.
Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate.
- Biology, MedicineOsteoarthritis and cartilage
- 1993
Concentration and size distribution of insulin-like growth factor-I in human normal and osteoarthritic synovial fluid and cartilage.
- Biology, MedicineArchives of biochemistry and biophysics
- 1995
The levels of IGF-I found in normal human cartilage are more than an order of magnitude lower than those which stimulate proteoglycan synthesis in humancartilage in culture, while the IGF-i levels in osteoarthritic cartilage lie in the range in which stimulation does occur.
Influence of cyclic loading on the nutrition of articular cartilage.
- Biology, MedicineAnnals of the rheumatic diseases
- 1990
Most major nutrients, such as glucose and oxygen, are small solutes and thus nutrition should not be affected by pumping, but the rate of desorption of a large solute (serum albumin), however, was increased by 30-100% in plugs subjected to cyclic loading.
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
- BiologyNature Genetics
- 1997
Analysis of atherosclerotic aorta in mice with a deficiency of apoliprotein E indicated that deficiency of u-PA protected against media destruction and aneurysm formation, probably by means of reduced plasmin-dependent activation of pro-MMPs.