Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.

@article{Pelletier2001OsteoarthritisAI,
  title={Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.},
  author={J. Pelletier and J. Martel-Pelletier and S. Abramson},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 6},
  pages={
          1237-47
        }
}
Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of the most common diseases among mammals. Although this musculoskeletal disorder has been described in mammals of many ages, having been reported in Egyptian mummies and in dinosaurs, its exact etiology is far from being fully understood. With the graying of the world population, it is of the utmost importance to find out more about the pathogenesis of the disease and thus allow the discovery of new… Expand
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  • 143
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  • 370
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  • 1
  • Highly Influenced
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  • 10
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  • 97
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References

SHOWING 1-10 OF 116 REFERENCES
Cytokines and their role in the pathophysiology of osteoarthritis.
  • 246
  • PDF
Genetic and Metabolic Aspects
  • 18
Metalloproteases and Their Modulation as Treatment in Osteoarthritis
  • 14
Gene therapy for osteoarthritis: new perspectives for the twenty-first century.
  • 20
T-cell mediated inflammatory pathway in osteoarthritis.
  • 99
Gene therapy for arthritis
  • 57
  • PDF
Serum markers of systemic disease processes in osteoarthritis.
  • 20
Pharmacologic therapy of osteoarthritis
  • 14
Intra-articular corticosteroid treatment in osteoarthritis.
  • 78
...
1
2
3
4
5
...