Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain

Abstract

Osteoarthritis (OA) is an age-related degenerative disease of cartilaginous tissues that is accompanied by hyperalgesia. Molecular cause and effect relationships between OA and pain remain to be elucidated. In this study, we have developed an experimental ex vivo organ co-culture system with dorsal root ganglia (DRGs) and knee synovial tissues from OA… (More)
DOI: 10.1007/s11033-011-0684-7

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