Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function.

@article{Abdelmagid2007OsteoactivinAA,
  title={Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function.},
  author={Samir M. Abdelmagid and Mary F. Barbe and Israel Arango-Hisijara and Thomas A. Owen and Steven N. Popoff and Fayez F. Safadi},
  journal={Journal of cellular physiology},
  year={2007},
  volume={210 1},
  pages={26-37}
}
Our laboratory previously showed that osteoactivin (OA) is a novel, osteoblast-related glycoprotein that plays a role in osteoblast differentiation and function. The purpose of this study was to examine the regulation of OA expression by BMP-2 and the role OA plays as a downstream mediator of BMP-2 effects in osteoblast function. Using primary osteoblast cultures, we tested different doses of BMP-2 on the regulation of OA expression during osteoblast development. To test whether Smad-1… CONTINUE READING