Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

@inproceedings{Downey2009OsteoChondroprogenitorSpecificDO,
  title={Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease},
  author={Charlene M. Downey and Chelsea R. Horton and Bradley A. Carlson and Trish E. Parsons and Dolph Lee Hatfield and Benedikt Hallgr{\'i}msson and Frank Robert Jirik},
  booktitle={PLoS genetics},
  year={2009}
}
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia. The disease has been postulated to result from a combination of different environmental factors, including contamination of barley by mold mycotoxins, iodine deficiency, presence of humic substances in drinking water, and, importantly, deficiency of selenium. This multifunctional trace element, in the form of selenocysteine… CONTINUE READING

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