Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.

@article{Chang2008OstealTM,
  title={Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.},
  author={Ming Kai Chang and Liza-Jane Raggatt and Kylie A. Alexander and Julia S. Kuliwaba and Nicola L. Fazzalari and Kate Schroder and Erin R. Maylin and Vera M. Ripoll and David A. Hume and Allison R Pettit},
  journal={Journal of immunology},
  year={2008},
  volume={181 2},
  pages={
          1232-44
        }
}
Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident tissue macrophages to bone physiology. Using immunohistochemistry, we showed that a discrete population of resident macrophages, OsteoMacs, was intercalated throughout murine and human osteal tissues. OsteoMacs were distributed among other bone lining cells within both endosteum and periosteum. Furthermore, OsteoMacs were coisolated with… CONTINUE READING

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