OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier

@inproceedings{Pulzova2011OspACD40DL,
  title={OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier},
  author={Lucia Borszekova Pulzova and Andrej Kovac and Rastislav Mucha and Patrik Mlyn{\'a}r{\vc}ik and Elena Benc{\'u}rov{\'a} and Marian Madar and Michal Nov{\'a}k and Mangesh Bhide},
  booktitle={Scientific reports},
  year={2011}
}
Lyme borreliosis is the most widespread vector-borne disease in temperate zones of Europe and North America. Although the infection is treatable, the symptoms are often overlooked resulting in infection of the neuronal system. In this work we uncover the underlying molecular mechanism of borrelial translocation across the blood-brain barrier (BBB). We demonstrate that neuroinvasive strain of Borrelia readily crosses monolayer of brain-microvascular endothelial cells (BMECs) in vitro and BBB in… CONTINUE READING
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