Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat

@article{Stevens1993OsmoticallyinducedNT,
  title={Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat},
  author={Martin J. Stevens and S. A. Lattimer and Mikiko Kamijo and C. Van Huysen and Anders A. F. Sima and Douglas A. Greene},
  journal={Diabetologia},
  year={1993},
  volume={36},
  pages={608-614}
}
Diabetic neuropathy results from progressive nerve fibre damage with blunted nerve regeneration and repair and may be complicated by nerve hyperexcitability resulting in pain. The naturally occurring amino acid taurine functions as an osmolyte, inhibitory neurotransmitter, and modulator of pain perception. It is also known to have neurotrophic actions. The compatible osmolyte hypothesis proposes that levels of intracellular organic osmolytes including taurine and myo-inositol, respond co… CONTINUE READING

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