Osmotic stress induces variation in cellular levels of ornithine decarboxylase-antizyme.

@article{Mitchell1998OsmoticSI,
  title={Osmotic stress induces variation in cellular levels of ornithine decarboxylase-antizyme.},
  author={John L. A. Mitchell and G G Judd and Aviva Leyser and Cheeyoung Choe},
  journal={The Biochemical journal},
  year={1998},
  volume={329 ( Pt 3)},
  pages={453-9}
}
The polyamines, and especially putrescine, play an integral role in the physiological response of cells to varying extracellular osmotic conditions. Ornithine decarboxylase (ODC) synthesis and stability, as well as the activity of the polyamine transporter, had all been reported to be very sensitive to media osmolarity in different cells and tissues, yet the mechanism of this complex, co-ordinated response was not known. In this study we have determined that all these aspects of osmotic-shock… CONTINUE READING

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