Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae.

@article{Bell2001OsmoticSC,
  title={Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae.},
  author={Gemma Bell{\'i} and E. Noem{\'i} Gari and Mart{\'i} Aldea and Enrique Montero Herrero},
  journal={Molecular microbiology},
  year={2001},
  volume={39 4},
  pages={1022-35}
}
Moderate hyperosmotic stress on Saccharomyces cerevisiae cells produces a temporary delay at the G1 stage of the cell cycle. This is accompanied by transitory downregulation of CLN1, CLN2 and CLB5 transcript levels, although not of CLN3, which codes for the most upstream activator of the G1/S transition. Osmotic shock to cells synchronized in early G1, when Cln3 is the only cyclin present, causes a delay in cell cycle resumption. This points to Cln3 as being a key cell cycle target for osmotic… CONTINUE READING

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