Osmotic stability of red cells in renal circulation requires rapid urea transport.

@article{Macey1988OsmoticSO,
  title={Osmotic stability of red cells in renal circulation requires rapid urea transport.},
  author={Robert I. Macey and L W Yousef},
  journal={The American journal of physiology},
  year={1988},
  volume={254 5 Pt 1},
  pages={C669-74}
}
Urea transport by the human erythrocyte occurs via an asymmetric-facilitated diffusion system with high Michaelis constants and high maximal velocities; the equivalent permeability in the limit of zero urea concentration is approximately 10(-3) cm/s (J. Gen. Physiol. 81: 221-237, 239-253, 1983). A physiological role for this system is revealed by numerical integration of the appropriate equations that show that rapid urea transport is essential for red cell stability in passing through the… CONTINUE READING