Osmotic regulation of substance P and neurokinin A peptide content and substance P binding sites in distinct hypothalamic nuclei of the rat.

@article{Larsen1992OsmoticRO,
  title={Osmotic regulation of substance P and neurokinin A peptide content and substance P binding sites in distinct hypothalamic nuclei of the rat.},
  author={P J Larsen and David S. Jessop and H. S. Chowdrey and Jens Damsgaard Mikkelsen and Stafford L. Lightman},
  journal={Peptides},
  year={1992},
  volume={13 4},
  pages={705-12}
}
Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites was observed in the perimeter of the magnocellular paraventricular and supraoptic nuclei, while the magnocellular nuclei themselves possessed a low receptor density. In control… CONTINUE READING

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