Osmotic demyelination syndrome after correction of chronic hyponatremia with normal saline.

@article{Lin2002OsmoticDS,
  title={Osmotic demyelination syndrome after correction of chronic hyponatremia with normal saline.},
  author={Shih-Hua Lin and Tom Chau and Chia-Chao Wu and S T Yang},
  journal={The American journal of the medical sciences},
  year={2002},
  volume={323 5},
  pages={259-62}
}
Rapid correction of severe chronic hyponatremia with hypertonic saline has been known to cause osmotic demyelination syndrome (ODS). Less recognized are the dangers of rapid correction with normal saline. A 60-year-old woman on thiazide diuretics for hypertension presented with profound hyponatremia (94 mmol/L) and hypokalemia (1.9 mmol/L) associated with volume depletion. Normal saline (2 L/day) and (KCl 40 mmol/day) were given for 5 days. Serum Na+ concentration rose to 106 mmol/L within 18… CONTINUE READING