Osmotic concentration and dilution in the mammalian nephron.

  title={Osmotic concentration and dilution in the mammalian nephron.},
  author={Carl W. Gottschalk},
The micropuncture evidence relating to the location and the mechanism for concentration and dilution of the urine is reviewed. As required by the countercurrent hypothesis for urine concentration, these data demonstrate that in the presence of antidiuretic hormone, the tubular urine is first concentrated in the descending limb of the loop of Henle and then diluted in the ascending limb of the loop before its final concentration in the collecting ducts. The loop of Henle is believed to function… CONTINUE READING