Osmotic Opening of the Blood–Brain Barrier: Principles, Mechanism, and Therapeutic Applications

@article{Rapoport2004OsmoticOO,
  title={Osmotic Opening of the Blood–Brain Barrier: Principles, Mechanism, and Therapeutic Applications},
  author={Stanley I. Rapoport},
  journal={Cellular and Molecular Neurobiology},
  year={2004},
  volume={20},
  pages={217-230}
}
  • S. Rapoport
  • Published 1 April 2000
  • Chemistry, Medicine
  • Cellular and Molecular Neurobiology
Abstract1. Osmotic opening of the blood–brain barrier by intracarotid infusion of a hypertonic arabinose or mannitol solution is mediated by vasodilatation and shrinkage of cerebrovascular endothelial cells, with widening of the interendothelial tight junctions to an estimated radius of 200 Å. The effect may be facilitated by calcium-mediated contraction of the endothelial cytoskeleton.2. The marked increase in apparent blood–brain barrier permeability to intravascular substances (10-fold for… Expand
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