Osmotherapy in brain edema: a questionable therapy.

@article{Grnde2012OsmotherapyIB,
  title={Osmotherapy in brain edema: a questionable therapy.},
  author={Per Olof Gr{\"a}nde and Bertil Romner},
  journal={Journal of neurosurgical anesthesiology},
  year={2012},
  volume={24 4},
  pages={407-12}
}
Despite the fact that it has been used since the 1960s in diseases associated with brain edema and has been investigated in >150 publications on head injury, very little has been published on the outcome of osmotherapy. We can only speculate whether osmotherapy improves outcome, has no effect on outcome, or leads to worse outcome. Here we describe the action and potentially beneficial and adverse effects of the 2 most commonly used osmotic solutions, mannitol and hypertonic saline, and present… CONTINUE READING
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