Osmosensor ProP of Escherichia coli responds to the concentration, chemistry, and molecular size of osmolytes in the proteoliposome lumen.

@article{Culham2003OsmosensorPO,
  title={Osmosensor ProP of Escherichia coli responds to the concentration, chemistry, and molecular size of osmolytes in the proteoliposome lumen.},
  author={Doreen E. Culham and JohnH. Henderson and Richard A. Crane and Janet M Wood},
  journal={Biochemistry},
  year={2003},
  volume={42 2},
  pages={
          410-20
        }
}
Transporter ProP of Escherichia coli mediates the cellular accumulation of organic zwitterions in response to increased extracellular osmolality. We compared and characterized the osmoregulation of ProP activity in cells and proteoliposomes to define the osmotic shift-induced cellular change(s) to which ProP responds. ProP-(His)(6) activity in cells and proteoliposomes was correlated with medium osmolality, not osmotic shift, turgor pressure, or membrane strain. Both K(M) and V(max) for proline… CONTINUE READING
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