Osmoregulation of neutral amino acid transport.

  title={Osmoregulation of neutral amino acid transport.},
  author={J G Chen and Stephen A. Kempson},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  volume={210 1},
Neutral amino acids are important organic osmolytes found in most osmotically stressed cells. During prolonged hypertonic stress, accumulation of neutral amino acids contributes to the cell volume recovery and may protect cellular proteins against salt denaturation. Hypertonicity activates system A transport, a major neutral amino acid transporter in mammalian cells, by a microtubule-dependent mechanism. Similar to the regulation of amino acid efflux induced by hypotonic-swelling, influx via… CONTINUE READING


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