Osmoregulation in the renal papilla: membranes, messengers and molecules.

  title={Osmoregulation in the renal papilla: membranes, messengers and molecules.},
  author={Rolf K. H. Kinne and Stefan H. Boese and Evamaria Kinne-Saffran and Birgit Ruhfus and Hanna Tinel and Frank Wehner},
  journal={Kidney international},
  volume={49 6},
This contribution summarizes recent progress in the understanding of the molecular basis of the release of organic osmolytes that occurs when inner medullary cells are confronted with a drop in osmolarity in their environment. For sorbitol release across the basolateral membrane an increase in intracellular calcium seems to be the prominent signal, initiated by G-protein activation, followed by phosphatidylcholine phospholipase activation and generation of arachidonic acid. The increase in… CONTINUE READING
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