Osmoregulation during pregnancy in the rat. Evidence for resetting of the threshold for vasopressin secretion during gestation.

@article{Durr1981OsmoregulationDP,
  title={Osmoregulation during pregnancy in the rat. Evidence for resetting of the threshold for vasopressin secretion during gestation.},
  author={Jacques A Durr and Barbara A. Stamoutsos and Marshall D. Lindheimer},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={68 2},
  pages={337-46}
}
Osmoregulation was studied in near term and age-matched Sprague-Dawley rats. Basal plasma osmolality (P(osm)) and plasma sodium (P(Na)) were 281+/-3 mosmol/kg and 134+/-3 meq/liter, respectively, on the 20th gestational day compared with 292+/-3 mosmol/kg and 140+/-1 meq/liter in virgin animals (P < 0.001), whereas P(urea) and plasma water content were similar in pregnant and control rats. These differences could not be reproduced in animals receiving progesterone, estrone, or a combination of… CONTINUE READING

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