Osmolyte mixtures have different effects than individual osmolytes on protein folding and functional activity.

@article{Warepam2015OsmolyteMH,
  title={Osmolyte mixtures have different effects than individual osmolytes on protein folding and functional activity.},
  author={Marina Warepam and Laishram Rajendrakumar Singh},
  journal={Archives of biochemistry and biophysics},
  year={2015},
  volume={573},
  pages={
          77-83
        }
}
Osmolytes are small organic molecules accumulated by organisms under stress conditions to protect macromolecular structure and function. In the present study, we have investigated the effect of several binary osmolyte mixtures on the protein folding/stability and function of RNase-A. For this, we have measured ΔGD(o) (Gibbs free energy change at 25°C) and specific activity of RNase-A mediated hydrolysis of cytidine 2'-3' cyclic monophosphate in the presence and absence of individual and… CONTINUE READING
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