Osmolyte Adjustments as a Pressure Adaptation in Deep-Sea Chondrichthyan Fishes: An Intraspecific Test in Arctic Skates (Amblyraja hyperborea) along a Depth Gradient

@article{Yancey2018OsmolyteAA,
  title={Osmolyte Adjustments as a Pressure Adaptation in Deep-Sea Chondrichthyan Fishes: An Intraspecific Test in Arctic Skates (Amblyraja hyperborea) along a Depth Gradient},
  author={Paul H Yancey and Ben Speers-Roesch and Sheila Atchinson and James D. Reist and Andrew R. Majewski and Jason R. Treberg},
  journal={Physiological and Biochemical Zoology},
  year={2018},
  volume={91},
  pages={788 - 796}
}
Accumulation of trimethylamine N-oxide (TMAO) by deep-sea animals is proposed to protect proteins against the destabilizing effects of high hydrostatic pressure (the piezolyte hypothesis). Chondrichthyan fishes (sharks, rays, and chimaeras) provide a unique test of this hypothesis because shallow-living species have elevated TMAO levels to counteract the destabilizing effects of high urea levels accumulated for osmoregulation. Limited interspecific studies of chondrichthyans reveal that… Expand
Cellular responses in marine animals to hydrostatic pressure.
  • P. Yancey
  • Medicine, Biology
  • Journal of experimental zoology. Part A, Ecological and integrative physiology
  • 2020
TLDR
For permanent deep-sea species, CSR/CHR mechanisms have not been directly tested, but evidence in Mariana Trench amphipods and snailfish suggest that HSP and desaturase genes, and possibly piezolyte synthesis, have undergone habitat-related selection. Expand
Unique osmoregulatory morphology in primitive sharks: an intermediate state between holocephalan and derived shark secretory morphology.
TLDR
The morphological similarities between the lobulate rectal-gland anatomy of primitive sharks and the secretory morphology of holocephalans may represent an intermediate state between Holocephali and derived shark species. Expand
An osmolality/ salinity-responsive enhancer 1 (OSRE1) in intron 1 promotes salinity induction of tilapia glutamine synthetase
TLDR
It is shown that hyperosmotic induction of glutamine synthetase represents a prominent part of this switch between hyper- and hypo-osmoregulation in Euryhaline tilapia, and that proper intron 1 positioning and the presence of an OSRE1 in introns 1 are required for precise enhancement of hyperosMotic glutamine Synthetase expression. Expand
Protein adaptation to high hydrostatic pressure: Computational analysis of the structural proteome
TLDR
The hypothesis that increased concentrations of osmolytes can provide a systemic increase in pressure stability of proteins from piezophilic organisms is put forward and experimental thermodynamic evidence is provided in support of this hypothesis. Expand
Deep-sea sharks: Relation between the liver's buoyancy and red aerobic muscle volumes, a new approach.
TLDR
The results showed that sharks characterized by a liver providing more hydrostatic force possess proportionally less red aerobic muscles than sharks having a liver that contributes less to their buoyancy, support low metabolic rates hence slow swimming speed. Expand
Dynamical Model for the Counteracting Effects of Trimethylamine N-Oxide on Urea in Aqueous Solutions under Pressure.
TLDR
A dynamical model in terms of hydrogen-bond lifetimes is developed for the hydrogen bonding propensities of cosolutes and water in an aqueous solution to proteins and provides an explanation for both the counteracting effects of TMAO on urea denaturation and the depth-dependent urea:TMAO ratio found in cartilaginous fish. Expand
How Do Urea and Trimethylamine N-Oxide Influence the Dehydration-Induced Phase Transition of a Lipid Membrane?
TLDR
This study suggests that urea significantly inhibits the dehydration-induced fluid-to-gel phase transition by strongly interacting with the lipid membrane via hydrogen bonds, which balances the reduced lipid hydration due to the decreasing water content. Expand
Is increased plasma TMAO a compensatory response to hydrostatic and osmotic stress in cardiovascular diseases?
TLDR
It is hypothesized that increased plasma TMAO serves as a compensatory response mechanism which protects cells from hydrostatic and osmotic stresses and is present in humans consuming seafood-rich diet which is thought to be health-beneficial. Expand
Exploring the influence of natural cosolvents on the free energy and conformational landscape of filamentous actin and microtubules.
TLDR
The effects of various types of natural cosolvents, such as urea and the osmolyte trimethylamine-N-oxide (TMAO), on the temperature- and pressure-dependent stability of their polymeric states, F-actin and microtubules are explored. Expand
Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats.
TLDR
Evidence is provided that a moderate increase in plasma TMAO does not have a negative effect on the circulatory system and seems to reduce diastolic dysfunction in pressure-overloaded hearts in rats. Expand
...
1
2
...

References

SHOWING 1-10 OF 41 REFERENCES
Does the physiology of chondrichthyan fishes constrain their distribution in the deep sea?
ABSTRACT The deep sea is the largest ecosystem on Earth but organisms living there must contend with high pressure, low temperature, darkness and scarce food. Chondrichthyan fishes (sharks and theirExpand
Decreasing Urea∶Trimethylamine N-Oxide Ratios with Depth in Chondrichthyes: A Physiological Depth Limit?
TLDR
The deepest chondrichthyans may be unable to accumulate sufficient TMAO to counteract pressure; however, deeper-living specimens are needed to fully test this hypothesis. Expand
Trimethylamine oxide, betaine and other osmolytes in deep-sea animals: depth trends and effects on enzymes under hydrostatic pressure.
TLDR
TMAO and, to a lesser extent, betaine are generally better stabilizers than other common osmolytes (myo-inositol, taurine and glycine), in terms of counteracting the effects of pressure on NADH Km of grenadier lactate dehydrogenase and ADP KM of anemone and rabbit pyruvate kinase. Expand
Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts.
TLDR
It was shown that, for lactate dehydrogenases (LDH), 250 mM TMAO fully offset an increase in NADH K(m) at physiological pressure, and partly reversed pressure-enhanced losses of activity at supranormal pressures, and support the hypothesis that this protein stabilizer counteracts inhibition of proteins by hydrostatic pressure. Expand
ELEVATED LEVELS OF TRIMETHYLAMINE OXIDE IN MUSCLES OF DEEP-SEA GADIFORM TELEOSTS : A HIGH-PRESSURE ADAPTATION?
Trimethylamine oxide (TMAO) as an osmolyte typically occurs at 20–70 mM in shallow-water marine teleost fishes. However, it has not been previously examined in deep-living species. We collectedExpand
Correlation of Trimethylamine Oxide and Habitat Depth within and among Species of Teleost Fish: An Analysis of Causation
TLDR
The data strongly support the hypothesis that TMAO is adaptively regulated with depth in deep‐sea teleosts, and no clear link between TmaO and lipid was found. Expand
Marine fish may be biochemically constrained from inhabiting the deepest ocean depths
TLDR
By capturing the world's second-deepest known fish, the hadal snailfish Notoliparis kermadecensis from 7,000 m, it is found that they have the highest recorded TMAO contents, which yield an extrapolated maximum for fish at about 8,200 m, previously unidentified evidence that biochemistry may constrain depth for a large taxonomic group. Expand
High contents of trimethylamine oxide correlating with depth in deep-sea teleost fishes, skates, and decapod crustaceans.
TLDR
High TMAO contents in muscles of other animals collected off the coast of Oregon may reflect diet, reduce osmoregulatory costs, increase buoyancy, or counteract destabilization of proteins by pressure. Expand
Solute accumulation in the deep-sea bacterium Photobacterium profundum
TLDR
The β-HB molecules represent a novel class of osmolytes, termed 'piezolytes,' whose cellular levels responded to hydrostatic pressure as well as osmotic pressure, since the organic solutes increased with increasing external NaCl in the medium. Expand
Trimethylamine oxide stabilizes teleost and mammalian lactate dehydrogenases against inactivation by hydrostatic pressure and trypsinolysis.
TLDR
For all the species and pressures tested, 250 mmol l(-)(1) TMAO reduced trypsinolysis significantly, and for all except S. altivelis, which was minimally affected by 101.3 MPa pressure, T MAO stabilized the LDH homologs and reduced pressure denaturation significantly. Expand
...
1
2
3
4
5
...