Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5.

@article{Caron2013OsmolarityDT,
  title={Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5.},
  author={Marjolein M J Caron and Anna E van der Windt and Pieter J. Emans and Lodewijk W. van Rhijn and Holger Jahr and Tim Welting},
  journal={Bone},
  year={2013},
  volume={53 1},
  pages={94-102}
}
INTRODUCTION Previous studies have shown that human articular chondrocytes in vitro are osmolarity-responsive and increase matrix synthesis under cartilage-specific physiological osmolarity. The effects of increased osmolarity on chondrogenesis of progenitor cells in vitro are largely unknown. We therefore aimed to elucidate whether hyperosmolarity facilitates their chondrogenic differentiation and whether Nfat5 is involved. MATERIALS AND METHODS ATDC5 cells and human bone marrow stem cells… CONTINUE READING

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