Osmolarity-dependent glycine accumulation indicates a role for glycine as an organic osmolyte in early preimplantation mouse embryos.

@article{Dawson1998OsmolaritydependentGA,
  title={Osmolarity-dependent glycine accumulation indicates a role for glycine as an organic osmolyte in early preimplantation mouse embryos.},
  author={Kara M. Dawson and Jennifer L Collins and Jay M Baltz},
  journal={Biology of reproduction},
  year={1998},
  volume={59 2},
  pages={
          225-32
        }
}
Mouse zygotes and early cleavage-stage embryos are sensitive to increased osmolarity. However, development can occur at higher osmolarities if any of a number of organic compounds are present. One of the most effective of these is glycine. We have found that the amount of glycine accumulated by embryos during in vitro culture from the zygote to two-cell stage depends on the osmolarity of the medium, with significantly more glycine accumulated at 310 or 340 mOsM than at 250 mOsM. The accumulated… CONTINUE READING

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