Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials

@article{Dobson2015OseltamivirTF,
  title={Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials},
  author={Joanna E Dobson and Richard J. Whitley and Stuart J Pocock and Arnold S Monto},
  journal={The Lancet},
  year={2015},
  volume={385},
  pages={1729-1737}
}
BACKGROUND Despite widespread use, questions remain about the efficacy of oseltamivir in the treatment of influenza. [...] Key Method Trials of oseltamivir for treatment of naturally occurring influenza-like illness in adults reporting at least one of the study outcomes were eligible.Expand
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References

SHOWING 1-10 OF 56 REFERENCES
Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments
TLDR
The effect on unverified pneumonia in children and for prophylaxis was not significant and there was no significant reduction in risk of unverified bronchitis, otitis media, sinusitis, or any complication classified as serious or that led to study withdrawal. Expand
Antivirals for Treatment of Influenza
TLDR
Meta-analyses of the few studies providing effects with adjustment for confounders suggest that, in high-risk populations, oral oseltamivir may reduce mortality and pneumonia associated with influenza A and inhaled zanamivIR may provide a net benefit over no treatment of influenza. Expand
Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial
TLDR
Oseltamivir was effective and well tolerated in the treatment of natural influenza infection in adults and was associated with higher symptom scores, less viral shedding, and improved health, activity, and sleep quality. Expand
Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group.
TLDR
Oseltamivir was associated with lower [corrected] symptom scores, less viral shedding, and improved health, activity, and sleep quality, and was well tolerated in the treatment of natural influenza infection in adults. Expand
Early oseltamivir treatment of influenza in children 1-3 years of age: a randomized controlled trial.
TLDR
Oseltamivir treatment started within 24 hours of symptom onset provides substantial benefits to children with influenza A infection. Expand
Oral oseltamivir treatment of influenza in children
TLDR
Oseltamivir treatment did not affect the influenza-specific antibody response and is an efficacious and well-tolerated therapy for influenza in children when given within 48 h of onset of illness. Expand
Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis
TLDR
The remaining evidence suggests oseltamivir did not reduce influenza related lower respiratory tract complications and neuraminidase inhibitors have modest effectiveness against the symptoms of influenza in otherwise healthy adults. Expand
Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza
TLDR
The data suggest that oral oseltamivir treatment reduces the duration and severity of acute influenza in healthy adults and may decrease the incidence of secondary complications. Expand
A double-blind, randomized, placebo-controlled multicenter study of oseltamivir phosphate for treatment of influenza infection in China.
TLDR
Oseltamivir was effective and well tolerated as treatment of early naturally acquired influenza in the intent-to-treat infected population and for the ITT population, similar results were observed. Expand
Oseltamivir effect on antibiotic-treated lower respiratory tract complications in virologically positive randomized trial participants.
  • M. Lipsitch, M. Hernán
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2013
TLDR
A meta-analysis of randomized controlled trials found that oseltamivir reduced the risk of antibiotic-treated lower respiratory tract complications by 28% (95% confidence interval], 11%– 42%) in outpatients and by 37% inOutpatients with laboratory-confirmed influenza infections. Expand
...
1
2
3
4
5
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